QWOP is a 2008 ragdoll-based Flash game created by former Cut Copy bassist Bennett Foddy. Players control an athlete named "Qwop" using only the Q, W, O, and P keys. The game has become a popular meme since it's outbreak in 2010.
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Many good memories of introducing this game to friends and taking turns trying to beat it. Legendary joke game. QWOP isn't only a great joke, however. At the time, QWOP was one of the few games besides the Metal Gear Solid franchise, and probably some others I’m not remembering, that confronted players directly with how they interact with video games. I think that's pretty notable. Or maybe I'm a pretentious jerk, who's to say?