Lupin, Jigen, and Goemon are at their Manhattan hideout plotting their next caper, when suddenly a large masked man bursts in. The man is escorted by a woman who proceeds to tell Lupin and the others that Fujiko has been kidnapped and is being held prisoner at one of the skyscrapers downtown. In order to get her back they must find the fountain of youth. When the two leave, Lupin decides to go and rescue Fujiko himself and sets off to save her. When arrives he discovers that the building is crawling with police, all under the command of Zenigata... so Lupin must enter through the building's ventilation to find Fujiko.