The Powerpuff Girls: Him and Seek for Game Boy Advance is a brawler type of game, with the plot revolving titular Powerpuff Girls going on a scavenger hunt for various items, as well as beating evil along the way.

The first three stages that can be played in any order act as a sort-of tutorial, and let you get aquainted with different girls' characteristics. Bubbles is quick and nimble when she needs to be, Buttercup is slow but hits harder, and Blossom is somewhere in the middle. All three characters can pefrorm close range punching attacks, as well as shoot lasers from further distance, but the laser spends energy that refills slowly. Each can also perform a unique action by holding R+A or R+B, and perform a super duper special move when all three are present. In these first three stages you can only play as a respective character and the game teaches you necessary mechanics. In Bubbles' level set in a zoo, you're told you can pick items and throw them, which is needed to complete that level, by finding all missing animals and throwing them back in the pens. After this, the items you find in other levels can be thrown at enemies, though they don't actually seem to do a lot of damage, and I found it more efficient to get close and personal. The combat isn't required for the Bubbles' stage (except for the boss battle), but for Blossom and Buttercup it's required. The combat is pretty simple and easy, but it's not mindless. Different enemies have different ranges of attacks and different weak spots, analizing your opponent is key to victory, and it's nice to have some variety. The bosses are much the same, find a way to abuse their weakness and the fight can end rather quickly. After you're done with the first stages, the girls assemble together and the story is pretty linear, you beat up a bunch of bad guys to get items from them.

When all three are together, you can switch between them and each have their own health and such, if one of the girls falls, the only way to restore them is to find Chemical X, which isn't common, although all three dying isn't very punishing, you're back to the start of the section you're on with all three alive, and you can save at any moment. It's not all flying around and fighting, there are a few moments where the gameplay changes. For Boogie Man, you're tasked with a simple rhythm game, tap an appropriate button when its at or near the circle. Once you're done visiting jail for Mojo Jojo, he hijacks the game and turns it into a Frogger clone to get to the base. I didn't really care for this mini-game to be honest. Lastly, for Him's lair, you have an autoscroller that is a sort of maze, you need to find the correct way out or you'll get teleported to the beginning of the section, and I didn't really like it as it felt a bit trial and error. There's also an optional pinball mini-game if you're looking for 100% completion. Speaking of 100% completion, after you beat all the bad guys, you're free to explore Townsville for more collectibles for the scavenger hunt, you're required to do some fetch questing, find one thing somewhere and exchange it for another, or just find the required item lying around. Thankfully it's not mandatory to get the credits rolling, I was three items short and got second place. Hey, second place is pretty good too, y'know.

The graphics are pretty decent, definitely feel like the show and the music is very good, and being one of the earlier games in GBA's life span, it doesn't sound very crunchy (compared to a different licensed game from the same year, Hey Arnold! The Movie). +1 point to Shin'en Multimedia.

Overall, an alright brawler with variety, the combat is actually kinda decent, though easy, but the gimmicks used for said variety don't always land, making it more of a mixed bag, though that doesn't make it a bad game.