Fantastic improvement over the first one in my eyes. I really felt like they just got rid of all the stuff I hated in the first one.
In the first one it felt like the inevitable failed runs had huge consequences and pretty much no benefit. Then you'd have to go through your gigantic rolodex of heroes to try and find a team that worked and probably fail again. It was both a slog, and it felt bad because you would lose all the time with no benefit.

Turning this into a run based roguelite with meta-progression basically fixes all this. You build your team, go on a run, fail or succeed to benefit from the meta-progression, so it doesn't feel depressing when you're losing and a huge bummer when you die cause you gain nothing, like in the first one.

Anyway, I had a great time, if you liked the first one but had similar problems with it that I did, check this out. If you didn't like the first one, maybe you'll like this one, it's pretty different except for the vibes and basic mechanics of the combat.