While not being a really complex game, Slay the Spire is very challenging, fun and creative. This makes it a really good roguelike in my opinion.
There are a LOT of challenges you can accomplish (such as steam acchievements), aswell as community challenges (every day updates) for the ones who really enjoy playing this game without stop.
This game helped me in very hard moments (I find it quite relaxing and demanding at the same time, which makes anxiety go away) and that is why is one of the best games of all time for me.