Dr. Mario 64 is a charming update to the original formula. While the core gameplay of aligning pills to clear viruses remains the star, Dr. Mario 64 sprinkles in new modes and even a quirky story involving Mario and Wario. It's an easy game to pick up, but reaching mastery (especially on higher difficulties) is a rewarding challenge. However, some of the new modes feel underdeveloped, and the presentation can feel a touch dated for modern audiences. Still, it's a solid puzzle experience, especially if you're longing for the N64 era.