Coming off the hype of the TV show, I went back to play Fallout 3 with Tale of Two Wastelands and have just completed the Fallout 3 section.

Personally I think Fallout 3 is the weakest of all the entries in the series. Most of the wasteland feels redundant and I felt like there were very few quest outside of the main quest and I spent extra hours running around the wasteland and still found myself hunting for content.

Fallouts systems haven't changed since FO3 that much and they still hold up reasonably well.