Everything about this game is phenomenal. The great art and aesthetic, amazing music, and truly great characters with some of the best voice work I've seen in a video game. The gameplay is also some of the best I've played, with every powerup and upgrade blending into a great playstyle, with nothing feeling truly weak. No enemy or boss felt truly unfair or aggravating, making every loss seem like your fault you can correct. The story is also great, being something that could only be truly realized through the medium of video games, with an ending that made me tear up after finishing that first run.
A must play for anyone even remotely into rougelikes.