Two Point Hospital is pretty self explanatory, you take on the role of a God like hospital manager in a world were diseases are funnier, but not less costly to treat. I say this because it's very hard to go broke in this game, it definitely leans more towards the more casual side of management games, but that's fine, especially considering the tone.
Some of the diseases are very funny too, it's really impressive how many different animations and models there are for all of them. New ones keep being introduced as the game goes on, but all you need for treatment is the proper building and staff so it never gets overwhelming. You can pause at any time too and build all the rooms you want if the need arises.
Overall, I think Two Point Hospital is pretty good. Your mileage may vary because it does get a little repetitive, but I think you would have to be insane to get all the stars in career mode because there are so many. The game is not short on content in that sense.