I feel like the story was too episodic-ish and most characters were irrelevant outside of the episode they belong, however I think it's the most beautiful and sad out of the other two games. I heavily appreciated the appearence of the topics of xenophobia, homophobia and toxic cristianity in the USA, how some people decide to live outside of society norms and live "free" and also all the stuff about the "journey" and the people you meet in the way. It's refreshing from all the family issues and drug abuse that appears in previous games.
I love how you have to balance between advancing in your goal to get to Mexico and being a good role model to your brother, and how those choices reflect in the endings. The fact that there are six endings and that you can't choose them right at the end (your past choices matter) is a huge improvement from previous games.
My only regret is that Max (and Chloe) don't have any importance in the game apart from a few dialogues with David in the last chapter. I was hoping they had some relevance in the plot, but I guess it's sweet how you know what happened after the events of the first game by listening to him.
Overall, a great sequel.