I haven't played every game in the genre, but as far as I'm concerned this is the best roguelike deck-builder there is. Excellently crafted, tragically difficult, addictingly entertaining.

The game is brutally challenging, but that's part of why I like it. I do A20 Heart runs and I only win maybe 10% of my runs. Most other games I would quit if I lost that much, but to me there is something so satisfying about winning that it makes up for losing most of the time.

It is a problem solving game at its core. If you feel like you want to hone skills in this department then I would recommend this game.