Uncharted 4 felt more like the end of a character rather than the end of a series, while this game feels like the swansong to the series; where everything in it feels like a best of portions the series all in one game with; characters that finally have the spotlight to shine where they didn't have the time prier.
The climax of the game is just the train part of Uncharted 2 but this time the train has a bomb on it, and yes it was just as awesome as U2's train section.