I believe that The Binding of Isaac: Rebirth has become a key genre defining title for modern roguelikes/lites. Despite some present flaws, they are vastly outshined by a consistently different gameplay loop. While your end goal might be the same, the way you get there or which goal you choose can differ wildly. A vast array of characters with a span of different mechanics allows the game to feel even more unique, and mods only crank this up to 11.