Felt in the mood to replay this after finishing New Vegas again (I was put in the mood for that after finishing the show). While I'm not finished this playthough, I highly doubt my opinions will change as I know this game pretty well.

This playthrough is heavily modded, using the Welcome to Paradise Wabbajack list as a base. I added the Be Exceptional progression rework, as well as True Damage and SCOURGE to re-balance the combat. I also installed miscellaneous weapons and armors from the previous games.

I think it's important to preface with this because I think this Fallout 4 is the best example of Bethesda's games getting exponentially better through mods.
What Bethesda is consistently amazing at with their games is world and atmosphere, and they have always been world class in this regard. I haven't played Starfield so I can't comment on it, but Skyrim and Fallout 3 are both incredible at developing a setting. Both those games are carried by this.

Why I love this game despite its myriad of notable flaws is that it combines their deftness at creating worlds with their best gameplay loop. An unusual quirk of Bethesda games is that almost every item in the world is interact-able in some way. In Fallout 4 this is given a new purpose, as literally every item that can be picked up can be used in crafting. Quests often revolve around completing dungeons, like all Bethesda games, but the new crafting system adds so many more personal sub-objectives to the dungeon crawling. If you're eyeing a particular upgrade for your power armor or your favourite gun you can just tag the required parts and go hunting.

The exploration is also boosted by the beautiful world and music. This is a great example of art direction > graphical fidelity. Even without graphics mods the game still looks good, and with a few tweaks it can look legitimately breathtaking. The soundtrack is also great. As always with Fallout, the radio stations add great classic songs from the 1930s-60s. My favourite in this game is probably "End of the World". The original score is also great. My favourite ambient track is easily "Rebuild, Renew". It just sounds incredibly soothing and hopeful, a powerful contrast against the destroyed world around you.

I won't deny the games main story is heavily flawed, especially compared to New Vegas' complexity, but there are still bright spots worth commending.
Nick Valentine might just be my favourite fallout character. His inner struggle with what it means to be a digital copy of a dead man is very compelling, and his voice performance is perfection. He's also a sick ass android detective.

I truly love this game, warts and all. New Vegas zealots can suck a fat one.