The stunlocking and unavoidable grabs started getting to me after the 7th-8th playthrough. Most of the damage you'll take is by being stuck in an animation you can't cancel.
Also some enemies can only stagger when they've finished certain animations (like picking ashley up), if you shoot them before you've wasted a bullet. much of the movement feels stiff and unrewarding.

Some specific ganados 100% ignoring you and running for ashley feels stupid and scripted, that behavior should be passed around during combat rather than assigned to only one of them.

Forcing the player to hold the the crosshair still during combat to focus is really dumb, they could have made the crosshair get smaller if you stood still or aimed at weak points rather than staring towards a fixed random direction.

If the aim was to make the game feel clunky like the original, they've succeeded.

[pre 1.0 release review]
The game is 100% doable solo, even Program X.
Definitely better for those who want to focus more on gameplay.
Multiplayer is either too chaotic or too easy, while running solo lets you have more freedom and control of the match.
Definitely feels pointless after the first few reborns you do, since nothing changes besides cosmetics.