Doomguy

A drunk Doomguy could destroy an entire city

Raiden

Ninja Raiden is definitely the sad drunk kind of guy and would bring the whole mood down

Miles Edgeworth

He's the one friend who drinks scotch and wine and pokes fun at the rest of the group for not being fancy like him

Jack Garland

He's the angry drunk kind of guy and would get thrown out of the bar for assaulting someone

Oersted

Oersted would have one bad experience while drinking before committing an arson attempt or something

Wario

Wario would rob everyone in the group and steal the car

Duke Nukem

I'm more scared of a drunk Duke than I am a drunk Doomguy

Gordon Freeman

He might end up talking if drunk which would spell out the end of humanity