200X ~ Dr. Wily steals and reprograms all of Dr. Light's industrial robots to control the world and its resources. Dr. Light upgrades Mega Man, a household robot, and sends him to stop Dr. Willy.

200X ~ Dr. Light and Mega Man receive a written challenge from Dr. Wily, telling them about his eight combat robots.

20XX ~ Dr. Wily changes sides and helps Dr. Light create a giant peacekeeping robot, only to steal it. Proto Man appears as a mysterious robot. Dr. Wily apparently perishes when his base collapses.

20XX ~ One year later, Dr. Cossack sends some robots to wreck havoc. Unbeknownst to Mega Man, Dr. Wily had survived their previous encounter and had bribed Dr. Cossack into doing his bidding by kidnapping his daughter, which Proto Man later rescues.

20XX ~ Dr. Wily revives four of the original robots (Mega Man 1) and four of his own (Mega Man 2).

20XX ~ Dr. Wily travels into the future and conspires with his future self to turn (future) Mega Man into Quint. He returns to the present and revives robots from Mega Man 2 and 3.

20XX ~ Dr. Willy, once more, revives previous robots, now from Mega Man 3 and 4.

20XX ~ Proto Man seemingly kidnaps Dr. Light and has a set of his own evil robots. When Mega Man infiltrates his base, the real Proto Man reveals himself, and it is revealed that the fake Proto Man was created by Dr. Wily.

20XX ~ Dr. Wily steals newly developed, high-performance robots from an exhibition. Also, once again, revives robots from Mega Man 4 and 5.

20XX ~ Dr. Wily finds the Stardroids, a series of robots from an ancient alien civilization, and reprograms them in an attempt to conquer the world.

20XX ~ Dr. Wily creates a time machine and uses it to travel to the past. Mega Man relives the events of Mega Man 1, 2 & 3, then clears Willy Tower.

20XX ~ One year after Mega Man 5, robots from all over the world compete in a tournament. Mr. X reprograms the finalists to take over the world. After defeating them, Mega Man finds out that Mr. X is actually Dr. Wily, who is captured and sentenced to prison.

20XX ~ Six months later, robots programmed to activate after no sign of Dr. Wily start to attack the city. Dr. Willy takes the opportunity to escape. Mega Man encounters Bass, who is supposedly trying to stop Dr. Wily but was actually created by him. Mega Man defeats Dr. Wily, and Bass interrupts to save him.

20XX ~ Duo, an extraterrestrial robot, fights against a mysterious evil robot above the Earth’s atmosphere. The two crash-land on Dr. Wily’s island. Duo joins forces with Mega Man, helping him against Dr. Wily and later saving his life.

20XX ~ A robot named "King" makes a declaration that robots should rule supreme over humans. He gathers an army, kicks Dr. Wily out of his castle, and claims it as his own. Mega Man and Bass temporarily team up to deal with King.

20XX ~ A mysterious robot from the future that looks like Mega Man attacks the city with six new robots. Mega Man and Bass set out to stop him, and find out he is a discarded prototype of Quint.

20XX ~ A law establishes that robots should have limited lifespans. Some robots created by Dr. Light start wrecking havoc. Dr. Wily is quick to notify citizens that the recent rampage was Dr. Light's doing, who is arrested. Mega Man fights to prove his creator's innocence and expose Dr. Wily's true intentions.

20XX ~ The "Roboenza" virus causes robots to start attacking humans. Dr. Wily turns out to be the maker of the virus and offers a cure only to those who are willing to work for him. He is defeated by Mega Man, Proto Man and Bass, but makes his escape, leaving behind enough of the cure to restore the infected.

20XX ~ Dr. Wily remembers the Double Gear System, a device he developed in his youth that pushed robots beyond their limits. He uses it in a new attempt to conquer the world. Mega Man employs a prototype of the Double Gear System to stop Dr. Willy. However, he escapes as his fortress collapses.

21XX ~ Dr. Cain uncovers a capsule with X, a robot created by Dr. Light. This leads to mass-produced robots similar to X, called Reploids. Some Reploids begin to act strangely and attack humans, being labeled Mavericks. X joins the leader of the Maverick Hunters, Zero, to stop the ambitions of Sigma, an advanced Reploid and ex-member of the Maverick Hunters who became Maverick himself.

21XX ~ Six months later, a new Maverick uprising begins, secretly led by Sigma. X destroys Sigma's new body, revealing his true form as the Sigma Virus and defeating it as well.

21XX ~ The Mother Computer of the Maverick Hunters' headquarters is hacked, resulting in fake data spiraling the world into chaos. Mavericks from Mega Man X and X2 are resurrected using their data. It turns out that Sigma is the mastermind of the operation. X confronts him and defeats him.

21XX ~ Reploid scientist Dr. Doppler identifies a virus that is forcing Reploids to go Maverick, dubbing it the Sigma Virus. He synthesizes a fake vaccine, leading to Mavericks rioting. X finds that Dr. Doppler had been infected by the virus and was manipulated into building a new body for Sigma. X defeats them both.

21XX ~ A strange phenomenon named "Erasure" causes Reploids' programs to suddenly be erased, leaving their bodies hollow. While investigating the cause, X and Zero fight resurrected Mavericks from Mega Man X2 and X3. They discover that two Reploids are behind the Erasure and defeat them.

21XX ~ The Repliforce, a Reploid army, is suspected to be responsible for a sabotage that caused thousands of deaths. Their leader, General, is indignant and starts a coup d'état. The Repliforce is considered Mavericks, and the Maverick Hunters are sent to stop them. It turns out Sigma orchestrated the conflict to wipe out both sides, but he is destroyed, and General sacrifices himself to save the Earth.

21XX ~ By Sigma's orders, the space colony Eurasia is sabotaged and set on a collision course towards Earth, while the Sigma Virus is scattered all over the world. The Maverick Hunters try to destroy Eurasia before it collides, but it still causes large damage. X and Zero go into the crash site, where they defeat Sigma. Zero perishes due to his wounds, and X wields his Z-Saber to honor him.

21XX ~ Humans seek refuge underground as Reploids work to restore the surface. Gate, a Reploid scientist, discovers an artifact that drives him mad, triggering Maverick outbreaks. X wipes out the Nightmare, a virus created by Gate using a sample of Zero's DNA. The real Zero returns, and along with X, they defeat Gate. Sigma is revived by Gate as a last resort, ending with the Hunters victorious. Considering himself dangerous, Zero plans to seal himself away for research.

21XX ~ Maverick crime rises as X retires, and Red Alert, a group of vigilantes, fights Mavericks. One of their key members, Axl, feeling used, leaves, prompting Red Alert to send after him. Zero helps Axl escape, leading to a challenge from Red Alert. Sigma's involvement is revealed, and the Hunters defeat him. Axl joins the Maverick Hunters.

21XX ~ Amidst the Maverick Wars, humanity flees to the Moon via an orbital elevator. X encounters an army of Sigmas led by Lumine, the director of the elevator, who reveals them as new generation Reploids immune from viruses. Lumine is kidnapped, prompting a showdown on the Moon where Sigma unveils his plan to eradicate the "old generation" and repopulate it with his "children". After defeating Sigma, the Hunters confront Lumine, who admits to orchestrating events and is subsequently defeated.

22XX ~ A century after the end of the Maverick Wars, the government of Neo Arcadia begins hunting down Reploids, unjustly labeling them as Mavericks. Ciel, a human scientist and leader of a resistance group of Reploids, finds an amnesiac Zero in a forgotten laboratory and helps him defeat Copy X, the one responsible for innocent Reploids being retired.

22XX ~ One year later, Zero learns from X about the Elf Wars, a century prior, and about the Dark Elf, a Cyber-elf created from Dr. Weil and Ciel's ancestor's combined research of Zero's body, which helped end the Maverick Wars. Elpizo, the new leader of the resistance, plots Neo Arcadia's destruction, urging Zero to intervene. Elpizo destroys X's body to harness Dark Elf's power, but is defeated. Elpizo apologizes for his actions. He and X live on as Cyber-elves.

22XX ~ Two months later, a spaceship emitting energy akin to the Dark Elf crashes. Zero and Ciel embark on an investigation, but Neo Arcadia captures Ciel. Dr. Weil resurfaces, reinstating control over Neo Arcadia and orchestrating a plan to harness the Dark Elf's power. Zero battles Omega and Copy X MK. II (both creations of Dr. Weil), ultimately defeating them.

22XX ~ As Neo Arcadia is now under the tyranny of Dr. Weil, humans are escaping to Area Zero, where Eurasia crashed during Mega Man X5. To avoid this, Dr. Weil forms a large offensive campaign. Zero stops Dr. Weil, allowing humans and Reploids to start a new life in Area Zero.

24XX ~ Two centuries later, society flourishes, thanks to equality between humans (now called Humanoids) and Reploids. Yet, the threat of Mavericks divides the world into Innerpeace and Outlands. A 14-year-old orphan, Vent/Aile, receives Biometal Model X (containing the essence of X), transforming into Mega Man. They confront Serpent, a Model W Mega Man (containing the essence of Dr. Weil), who seeks ultimate power. They prevail, vowing to safeguard their world anew.

24XX ~ Almost five years later, Model W's remnants spur Maverick outbreaks. The Hunter's Guild, born from Serpent's legacy, seeks ancient tech, but some, known as Raiders, pursue power for themselves. Teenagers Grey/Ashe, imbued with Model A (created by Master Albert), combat foes and uncover Albert's scheme to harness Model W's power. Rejecting fate, they vanquish Albert, ending the chaos.

Post 5XXX ~ In the far future, much of the world is covered in water. Teisel, Tron's older brother, borrows a large amount of money to build a large pirate airship. Teisel and his squad set off, leaving Tron behind, who soon realizes they've been swindled. When Teisel is kidnapped, Tron vows to settle the debt to rescue her brothers.

Post 5XXX ~ People live on islands using ancient technology powered by refractors. Diggers like MegaMan Volnutt search for these refractors, hoping to uncover the legendary Mother Lode, which could power the world indefinitely. Upon landing on Kattelox Island, MegaMan battles air pirates and unearths the island's secrets, eventually confronting the enigmatic robot Juno, whose plans threaten the island's inhabitants.

Post 5XXX ~ MegaMan and company continue their pursuit of the Mother Lode. A businessman, constructs a massive airship to penetrate the storm surrounding Forbidden Island, taking MegaMan and others aboard. However, en route, a disguised Yuna attempts to deter them. Yuna and Sera are the Mother Units who rule over the systems on Elysium, a space-orbiting colony. MegaMan follows Sera to Elysium to prevent her from using the Carbon Reinitialization Program, but becomes trapped there.