It didn't get to me when I played it, but I was in a call with my friend who was playing it, and we both lost our cool when she was reading Rosalina's Story out-loud (it was Chapter 4).
The Legend of Zelda: Twilight Princess
Mother 3
Haven't even beaten the game yet, but the scene where Flint... is given the Drago fang... got me.
Kingdom Hearts II
Kingdom Hearts
It's haaaard to let it go...
Klonoa: Door to Phantomile
Final Fantasy VII
No points for guessing which part of the game it was.