Just some chill serotonin games or stuff that just makes the world feel better. Many of these are building/farming games because that's what people generally use for that.
Its also horny, but like in a fun way instead of creepy.
Quiplash
Include all Jackbox games tbh
Wandersong
Nairi: Tower of Shirin
80 Days
Dr. Langeskov, The Tiger, and The Terribly Cursed Emerald: A Whirlwind Heist
Mini Metro
Katamari Damacy
Chulip
I hesitated to put this on good vibe serotonin because of just how frustrating the gameplay and mechanics and forward momentum can be, but its so darn charming it kinda beats that out.
Chibi-Robo!
Gravity Rush
Ghost Trick: Phantom Detective
Much more serious than the other entries here. But it carries a fervent belief in fighting for a better future for your loved ones that I can't help but keep it on here.
Paper Mario: The Thousand-Year Door
Wattam
Paper Mario
Professor Layton and the Curious Village
Please assume this counts for the entire Professor Layton series
Slime Rancher
Sayonara Wild Hearts
Harvest Moon 64
Is this the good one? No idea
Baba is You
EarthBound
Costume Quest
Rune Factory 2: A Fantasy Harvest Moon
My girlfriend said it was the the one to start with