There's powers higher than mankind.

Also it's a visual novel.

Blue Moon is a song in the game and the game starts on a shot of the moon.
You also can die and also kill things with one strike, and you can wield knives.

Consumption of hallucinogens

Project Moon, Type Moon, they have Moons and are also visual novel makers.

Zero is the progenitor of the Maverick Virus and gives it to Sigma who reincarnates himself while also infecting others, Zero is also a robot who wears White and Red and has Blonde Hair while X the main protagonist primarily wears Blue.

Sonic is blue and can kill things in one hit, Knuckles is Red and from an ancient tribe. Sonic is Shiki, Knuckles is Arcueid, I am drunk.

There's a DLC with Vampires, and you can recreate the cast of Tsukihime in it if you wanted to.

Kohaku is like the funny devil man Hazama. Here's artwork by ILoveKohaku97 which shows her dressed as Hazama it's based.

Horror Vibes and Cute Girls, also death.

You kill things.

You can program Melty Blood characters into the game.

Pac-Man starts the game shaped like a moon, and can die, which is just like Tsukihime.

Protagonist has black hair and wears glasses, he also uses a knife.

Both have music

There is a stage that starts you on the moon.

Boo's Mansion/Tohno Mansion

Also Mario can die.

The protagonist gets possessed by an evil entity that reincarnates.

DIO is a vampire who has blonde hair, and wears red, there's also night time stages.

You slice people to instantly kill them.

Joker is Shiki for beta males.

Zombies

Time Vampires.

You have sexual intercourse with women

There are undead creatures.

Originator

Both have underaged characters engaging in dangerous activity.

Vampires

These are both technically indie projects, the sole difference being that Yandere Simulator is irredeemably shit.

There are night missions.

You have intercourse with women

Both games have blood in them.

Scary

Both have music

It has the moon in it.

Gwyndolin is literally Arcueid.

Sexual Content

Vergil wears blue and cuts things, Dante has shoulder length hair and wears red, also the moon is on the cover.

Weird shit happens

There's a vampire and you kill a being called Chaos

Some levels take place at night.

They both have music.

Weeb shit that defined a generation

Kingdom Hearts is just a big moon in the sky.

Moon is in the title of both

Moon is in the fucking title.

My friend is extremely mixed on both of these but I'm just gonna say it's because you play a guy who cuts people and is descended from killers or some shit.

Japan

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There's a lot of bad endings, also both games are visual novels.

Sexual Content

Misogyny

Ken is Blonde and wears Red.

It's a visual novel

The narrator's of both are insane

One of the guest characters is from Melty Blood.

You are a vampire